ComPPI: a protein-protein interaction database extended with subcellular protein localization information

Availability and major properties of the ComPPI database

This page will contain the freely downloadable protein-protein interaction databases for S.cerevisiae, C.elegans, D.melanogaster and H. sapiens species. These databases will contain information on the subcellular localization of proteins and will retain thos interactions where both interacting partners have at least one common subcellular localization. The user will be able to define organelle-specific subnetworks. If you want to have a personal message at the moment the database will be uploaded please write to us here.

Major properties of the ComPPI database:

• filtration of interactions, where interacting partners are not in the same cellular compartment
• databases for 4 widely investigated model organisms
• compilation of localization data from several databases
• plug-in like input options of different protein-protein interaction and localization databases

Related previous studies of the LINK-Group

For background and preliminary studies please visit this website: http://www.linkgroup.hu/proteinnetworks.php or look for the papers below.

1. Simkó, G. I., Gyurkó, D., Veres, D. V., Nánási, T. and Csermely, P. (2009) Network strategies to understand the aging process and help age-related drug design. Visit it at arXiv.org!
   Download Genome Medicine 1, 90!
2. Antal, M.A., Böde, C. and Csermely, P. (2009) Perturbation waves in proteins and protein networks: Applications of percolation and game theories in signaling and drug design. Curr. Prot. Pept. Sci. 10, 161-172, IF: 3.3.
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3. Kiss H.J.M., Mihalik, Á., Nánási, T. Ory, B., Spiró, Z., Soti, C. és Csermely, P. (2009) Ageing as a price of cooperation and complexity: Self-organization of complex systems causes the ageing of constituent networks. Bio Essays 31, 651-664 . Visit it at arXiv.org! Available from Nature Precedings
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4. Csermely, P. (2008) Creative elements: network-based predictions of active centres in proteins, cellular and social networks. Trends Biochem. Sci. 33, 569-576, Download it! Visit it at arXiv.org!
   
5. Palotai, R. Szalay, M.S. and Csermely, P. (2008) Chaperones as integrators of cellular networks: changes of cellular integrity in stress and diseases. IUBMB Life 60, 10-18, arxiv.org/0710.1622, IF: 2.3 Download it!
   Visit it at arXiv.org!
6. Csermely, P. (2001) Chaperone-overload as a possible contributor to “civilization diseases”: atherosclerosis, cancer, diabetes. Trends in Genetics, 17, 701-704
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7. Nardai, G., Csermely, P. and Sőti, Cs. (2002) Chaperone function and chaperone overload in the aged, Exp. Gerontol, 37, 1255-1260
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8. Sreedhar, A.S., Mihály, K., Pató, B., Schnaider, T., Steták, A., Kis-Petik, K., Fidy, J., Simonics, T., Maráz, A. and Csermely, P. (2003) Hsp90 inhibition accelerates cell lysis: anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events. J. Biol. Chem. 278, 35231-35240
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9. Sőti, Cs., Pál, Cs., Papp, B. and Csermely, P. (2005) Chaperones as regulatory elements of cellular networks. Curr. Op. Cell Biol. 17, 210-215
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10. Nardai, G., Végh, E., Prohászka, Z. and Csermely, P. (2006) Chaperone-related immune dysfunctions: An emergent property of distorted chaperone-networks. Trends Immunol. 27, 74-79
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    Supplementary material
11. Csermely, P. and Sőti, C. (2006) Cellular networks and the aging process. Arch. Physiol. Biochem. 112, 60-64
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12. Csermely, P., Blatch, G. and Sőti, C. (2007) Chaperones as parts of cellular networks. Adv. Exp. Med. Biol. 594, 55-63
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    http://www.eurekah.com/abstract.php?chapid=2946&bookid=222&catid=15
13. Rutherford, S. L., Knapp, J. R. and Csermely, P. (2007) Hsp90 and developmental networks. Adv. Exp. Med. Biol. 594, 190-197
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    (http://eurekah.com/abstract.php?chapid=3001&bookid=222&catid=15)
14. Csermely, P. and Sőti, C. (2007) Aging cellular networks: chaperones as major participants. Exp. Gerontol. 42, 113-119,
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    Visit it at arXiv.org!
15. Korcsmáros, T., Kovács, I. A., Szalay, M. S. and Csermely, P (2006) Molecular chaperones: The modular evolution of cellular networks. Journal of Bioscience 32 (3): 441-446. IF: 1,5 Download it!
16. Szalay, M., Kovács, I.A., Korcsmáros, T., Böde. C. and Csermely, P. (2007) Stress-induced rearrangements of cellular networks: consequences for protection and drug design. FEBS Lett. 581 (19): 3675-80. IF: 3,5
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    Visit it at arXiv.org! IF: 3.5