Metabolic networks

Description:

This project is based on the expertise of the Pál-Papp duo on flux-balance analysis and combines this knowledge with their recent advances in high-throughput experimental techniques on in vitro evolution of single-cell organisms. The robustness of cellular networks is planned to be tested using the above complex methodology in conjunction of the development of novel approaches in drug design strategies.

Publications:

1. Papp, B., Pal, C. and Hurst, L. D. (2004) Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature 429, 661-664.
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2. Hurst, L.D. and Pal, C. (2005) Dissecting dispensability. Nature Genet. 37, 214-215.
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3. Pal, C., Papp, B. and Lercher, M.J. (2005) Adaptive evolution of bacterial metabolic networks by horizontal gene transfer. Nature Genet. 37, 1372-1375
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4. Pál, C., Papp, B., Lercher, M.J., Csermely, P., Oliver, S.G. and Hurst, L.D. (2006) Chance and necessity in the evolution of minimal metabolic networks. Nature 440, 667-670 paper
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   Supplementary material
   • Comment on the paper at BBC News.
   • Hungarian comment at the Hungarian Academy of Sciences.
   • Hungarian comment in the journal "Népszabadság".
5. Harrison, R., Papp, B., Pal, C., Oliver, S.G. and Delneri, D. (2007) Plasticity of genetic interactions in metabolic networks of yeast. Proc. Natl. Acad. Sci. USA 104, 2307-2312
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