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Actual projects
- Network modules/communities
Our work focuses on special methods for analysing the fine structure of complex networks comprising many interacting elements with directed or undirected links. More... - Network stability, dynamics and spatial games
This complex project is aimed to understand the rules of network evolution and the emergence of network complexity. In hope to find key aspects in this multi-task process, we combine three independent, but interrelated approaches. More... - Network perturbation analysis
This project investigates the perturbations of networks identifying key network elements, dissecting the propagation of signals and noise and analyzing signal transmission and the dissipation of noise in biological systems.
More... - Protein structure networks
This project is identifying important elements of protein structure by network analysis, where we model the protein structure by amino acid or hydrogen-bond networks. Our target proteins include those of the cytochrome P450 family as key members of drug metabolism. - Protein interaction networks, stress, apoptosis and aging
In this project we analyze the changes of protein-protein interaction networks in stress, in apoptosis, during aging and in disease. We extend our studies to other types of networks trying to identify common topological transitions in networks during crisis and recovery. We study the disassembly and reassembly of network modular structure during and after stress, where creative network elements, such as molecular chaperones play a key brokerage role in the latter process. - Signalling networks
The SignaLinK group is working with signalling networks in collaboration with Péter Csermely, Tibor Vellai, Tamás Vicsek and Bálint Szabó. Our aim is to experimentally prove our hypothesis on embed adaptation of network topology in C. elegans. - Metabolic networks
This project is based on the expertise of the Pál-Papp duo on flux-balance analysis and combines this knowledge with their recent advances in high-throughput experimental techniques on in vitro evolution of single-cell organisms. - Networks and drug design
Despite improved rational drug design and a remarkable progress in genomic, proteomic and high-throughput screening methods, the number of novel, single-target drugs fell much behind expectations during the past decade. The project is aimed to find novel drug targets, which are less vulnerable to the development of resistance, and to the mobilization of secondary pathways of cellular networks. More...
Actual projects:
Published by the LINK-Group | Editor: Péter Csermely | Last updated on 12. Jan. 2011.
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