Networks and drug design

Description:

Despite improved rational drug design and a remarkable progress in genomic, proteomic and high-throughput screening methods, the number of novel, single-target drugs fell much behind expectations during the past decade. The project is aimed to find novel drug targets, which are less vulnerable to the development of resistance, and to the mobilization of secondary pathways of cellular networks. As a part of this effort, design strategies to find appropriate target-sets of multi-target drugs are to be developed using multiple perturbations of protein-protein interaction networks.

Publications:

1. Nussinov, R., Tsai, C.-J. and Csermely, P. (2011) Allo-network drugs: harnessing allostery in cellular networks. Trends in Pharmacol. Sci. 32, 686-693, IF: 11.0 -- a cover story. Download it!
2. Farkas, I.J., Korcsmáros, T., Kovács, I.A., Mihalik, Á., Palotai, R., Simkó, G.I., Szalay, K.Z., Szalay-Bekő, M., Vellai, T., Wang, S. and Csermely, P. (2011) Network-based tools in the identification of novel drug-targets. Science Signaling 4, pt3. Download the paper!
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3. Spiró, Z., Kovács I.A. and Csermely, P. (2008) Insights from networks of drugs, therapies, targets and diseases and the prediction of novel drug targets. J. Biol. 7, 20.
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4. Antal, M.A., Böde, C. and Csermely, P. (2009) Perturbation waves in proteins and protein networks: Applications of percolation and game theories in signaling and drug design. Curr. Pept. Prot. Res. 10, 161-172  Download it!
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5. Agoston, V., Csermely, P. and Pongor, S. (2005) Multiple, weak hits confuse complex systems. Phys. Rev. E. 71, 051909,
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6. Csermely, P., Ágoston, V. and Pongor, S. (2005) The efficiency of multi-target drugs: the network approach might help drug design. Trends Pharmacol. Sci. 26, 178-182
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7. Korcsmáros, T., Szalay, M., Böde. C., Kovács, I.A., and Csermely, P. (2007) How to design multi-target drugs: Target-search options in cellular networks. Exp. Op. Drug Discovery 2: 1-10. Download it!